HORDB

ID: hor002874
Uniprot ID: Q9NDE8
Protein name: QAPRFF-amide
Gene name: MRP
Organism: Aplysia californica (California sea hare)
Family: NA
Source: animal
Expression: Expressed in the CNS and peripheral tissues (the digestive tract, vasculature, and the reproductive organs).
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QAPRFF
Length: 6(148-153)
Propeptide: MCTRPGLAALLVLMTSCASSFSRADTQSASAAALSAASADAQAARQQQEQHLVAQQQQQQQQQQQHSNNNEPQQRAPSLDPYYRSLLDGSQGGQLFAPAQPVSQPDLSPDFSNPMGSSLSQSGTPEDSDTKVDTRGAAPKFFGKKRGQAPRFFGKKRAMAPKFFGKKSSEFPTSNSEQLALDTRGSPRFFGKKSFPESNREQRGSPRFFGKKRFDENVDIDERAAPRFFGKKSSGESAGDSGYISVASRGSPRFF
Signal peptide: MCTRPGLAALLVLMTSCASS
Modification: T6 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Be inhibitory on Aplysia esophagus, penis retractor muscle, and body wall muscle
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002874_AF2.pdb

hor002874_ESM.pdb

Mass:	85424	Formula:	C37H52N10O8
Absent amino acids:	CDEGHIKLMNSTVWY	Common amino acids:	F
pI:	10.55	Basic residues:	1
Polar residues:	0	Hydrophobic residues:	3
Hydrophobicity:	-36.67	Boman Index:	-1269
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	16.67
Instability Index:	2786.67	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 10531464
Title: The Aplysia mytilus inhibitory peptide-related peptides: identification, cloning, processing, distribution, and action.